SGLT-2 inhibitors and Fournier’s gangrene

SGLT-2 inhibitors, sometimes called “gliflozins”, are medicines used to treat type 2 diabetes, heart failure and chronic kidney disease.

Examples include:

They may also be included in combination medicines. Check the name of your medicine or ask a pharmacist if you are unsure.

What is Fournier’s gangrene?

Fournier’s gangrene is a very rare but serious infection affecting the genitals or the area between the genitals and anus.

It can affect both men and women and may become life-threatening if it is not treated quickly.

Seek urgent medical help if you develop:

severe pain or tenderness around your genitals or the area between your genitals and anus
redness or swelling in this area
a high temperature or fever
a general feeling of being unwell

A genital or urinary infection, or an abscess in this area, may sometimes develop before the more serious infection.

If you develop these symptoms:

stop taking your SGLT-2 inhibitor
seek urgent medical attention immediately
tell the healthcare professional that you are taking an SGLT-2 inhibitor and are concerned about Fournier’s gangrene

Contact the practice urgently during opening hours or call NHS 111 if we are closed.

If you are seriously unwell, go to A&E or call 999.

Do not stop taking this medicine routinely if you do not have symptoms.

Speak to a doctor, nurse or pharmacist if you have any concerns about your treatment.